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Cocaine binds to the norepinephrine transporter (NET) and other closely related monoamine transporters (DAT & SERT) at a common core area known as the central substrate-binding site, also referred to as the S1 pocket (Acharya Dahal et al., 2014

& Voeltz, G

On the contrary, in Gltp cKO, we propose a gain-of-toxic function phenotype, possibly triggered by the accumulation of GalCer in the ER

The initial condition for each sensitivity differential equation is zero 57

Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025